#Quest diagnostics doral appointment full

Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined. If an opioid is initiated in a patient already taking DORAL, prescribe a lower initial dose of the opioid and titrate based upon clinical response.Īdvise both patients and caregivers about the risks of respiratory depression and sedation when DORAL is used with opioids. In patients already receiving an opioid analgesic, prescribe a lower initial dose of DORAL than indicated in the absence of an opioid and titrate based on clinical response. If a decision is made to prescribe DORAL concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. Because of these risks, reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue DORAL or reduce the dosageĥ.1 Risks from Concomitant Use with OpioidsĬoncomitant use of benzodiazepines, including DORAL, and opioids may result in profound sedation, respiratory depression, coma, and death. Abrupt discontinuation or rapid dosage reduction of DORAL after continued use may precipitate acute withdrawal reactions, which can be life-threatening. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose.

The continued use of benzodiazepines, including DORAL, may lead to clinically significant physical dependence.Before prescribing DORAL and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. The use of benzodiazepines, including DORAL, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.Follow patients for signs and symptoms of respiratory depression and sedation Limit dosages and durations to the minimum required. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS ABUSE, MISUSE, AND ADDICTION and DEPENDENCE AND WITHDRAWAL REACTIONS To reduce the risk of withdrawal reactions, use a gradual taper to discontinue DORAL or reduce the dosage ( Abrupt discontinuation or rapid dosage reduction of DORAL after continued use may precipitate acute withdrawal reactions, which can be life-threatening.Before prescribing DORAL and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction ( Follow patients for signs and symptoms of respiratory depression and sedation (.

Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.

#Quest diagnostics doral appointment full

WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS ABUSE, MISUSE, AND ADDICTION and DEPENDENCE AND WITHDRAWAL REACTIONS See full prescribing information for complete boxed warning.